NCT04407026

Oral and Systemic Levels of TFF-1 and TTF-3 in Periodontal Diseases

Two Novel Peptides Associated With Stage 3 Periodontitis: TFF-1 and TFF-3

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Aydin Adnan Menderes University · Academic / Other
• Sex: All
• Age: 25 Years – 49 Years
• Healthy volunteers: —

Summary

Trefoil factor family (TFF) consists of a group of small peptides that have key roles in host immune response and repair of tissue damage. Interleukin (IL)-1β is a regulatory proinflammatory cytokine in periodontal inflammation. This study aimed to investigate the levels of TFF-1, TFF-3 and IL-1β in gingival crevicular fluid (GCF), saliva and serum of patients with gingivitis, stage 3 periodontitis and healthy individuals.

Detailed description

A total of one hundred participants were enrolled for the study. All individuals were assessed clinically and radiographically. Full-mouth clinical periodontal examinations were performed by the measurements of probing depth (PD), clinical attachment level (CAL), gingival index (GI), plaque index (PI) and bleeding on probing (BOP). All these measurements were recorded at six sites around each tooth with a manual periodontal probe. The participants were categorized into three groups: healthy controls (n=25), patients with gingivitis (n=25) and patients with periodontitis (n=50). Gingival crevicular fluid, saliva and serum samples were collected from each participant one day after the clinical periodontal measurements. TFF-1, TFF-3 and IL-1β levels of these biofluids were determined using the enzyme-linked immunosorbent assay.

Conditions

• Periodontal Diseases

Interventions

Type	Name	Description
BIOLOGICAL	biofluids	Gingival crevicular fluid, saliva and serum samples were obtained.

Timeline

• Start date: 2017-07-01
• Primary completion: 2018-03-01
• Completion: 2018-04-01
• First posted: 2020-05-29
• Last updated: 2020-05-29

Locations

1 site across 1 country: Turkey (Türkiye)