NCT04401085

COVID-19: Herd Immunity Study in the Czech Republic

Herd Immunity Study SARS-CoV-2-CZ-Preval

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 27,000 (actual)
• Sponsor: Institute of Health Information and Statistics of the Czech Republic · Other Government
• Sex: All
• Age: 8 Years – 89 Years
• Healthy volunteers: Accepted

Summary

The aim of the SARS-CoV-2-CZ-Preval study is to quantify the prevalence of individuals with a history of SARS-CoV-2 coronavirus infection in the Czech population, except for those diagnosed with COVID-19 by methods based on direct detection of SARS-CoV- 2, including individuals with a subclinical course of the disease.

Detailed description

COVID-19 is caused by a new type of coronavirus called SARS-CoV-2. It is a highly infectious disease, manifested mainly by fever, respiratory problems, muscle pain, and fatigue. However, despite the publication of hundreds of papers in the literature, fundamental information about the spread and course of the disease is still lacking in COVID-19. One of such key pieces of information is the prevalence of asymptomatic individuals with SARS-CoV-2 infection, which has a significant effect on the dynamics of the spread of COVID-19 in the Czech Republic and within individual regions and localities. The SARS-CoV-2-CZ-Preval study is aiming at quantification of the prevalence of individuals with a history of SARS-CoV-2 coronavirus infection in the Czech population, except for those diagnosed with COVID-19 by methods based on direct detection of SARS-CoV- 2, including individuals with a subclinical course of the disease.

Conditions

• COVID
• SARS-CoV 2

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	SARS-CoV-2 diagnostic rapid test	The rapid test detects the presence of antibodies against SARS-CoV-2 in the IgM and IgG class by the immunochromatographic reaction. It cannot detect early infection, the antibodies will probably appear two weeks after possible infection. The collection will be performed by finger puncture.
DIAGNOSTIC_TEST	Quantitative analysis of SARS-CoV-2 antibodies	The subsample from Olomouc region (Olomouc, Uničov, Litovel) is based on venous blood sampling and archiving for subsequent quantitative analysis of SARS-CoV-2 antibodies. These tests detect immunoglobulins M and G (IgM and IgG).

Timeline

• Start date: 2020-04-23
• Primary completion: 2020-05-01
• Completion: 2020-05-01
• First posted: 2020-05-26
• Last updated: 2020-06-01

Locations

1 site across 1 country: Czechia