NCT04400292

Sentinel Lymph Node Mapping in Esophageal Cancer Using ICG Dye and NIR Imaging

Does the Concept of the Sentinel Lymph Node Apply to Esophageal Cancer? A Prospective Assessment of Near-infrared Image-guided Lymphatic Mapping and Sentinel Lymph Node Identification in Esophageal Cancer

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Memorial Sloan Kettering Cancer Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to find out whether sentinel lymph node (SLN) mapping with ICG dye and NIR imaging can be used to identify esophageal or esophagogastric junction cancer that has spread to the lymph nodes. If SLN mapping is successful in these types of cancer, surgeons in the future could identify the sentinel lymph nodes and only remove these instead of removing all the lymph nodes which is currently done.

Conditions

• Esophageal Cancer

Interventions

Type	Name	Description
OTHER	Injection of indocyanine green (ICG)dye	Patients will receive a perilesional injection of indocyanine green (ICG) before the laparoscopic phase of the esophagectomy.
DEVICE	Near-Infrared Image-Guided	Real-time near-infrared (NIR) fluorescence imaging will be performed by use of the Novadaq PINPOINT minimally invasive system with a laparoscopic camera.
PROCEDURE	Sentinel Lymph Node (SLN) mapping	Any identified SLNs will be dissected during the standard completion lymphadenectomy and esophagectomy.

Timeline

• Start date: 2020-05-20
• Primary completion: 2026-05-01
• Completion: 2026-05-01
• First posted: 2020-05-22
• Last updated: 2025-07-03

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study