NCT04399460

The Effects of Long-term Consumption of Full-fat Dairy Products on Satiety, Body Weight and Glycemic Control

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 93 (estimated)
• Sponsor: University of Toronto · Academic / Other
• Sex: All
• Age: 30 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The proposed study looks at the effect of long-term diet modification with or without full-fat dairy products or restrictive eating on body weight, body composition and cardiometabolic markers in healthy overweight/obese men and women.

Detailed description

A total of 93 males and females will participate in the study at the University of Toronto. At the beginning and after 12 weeks, body weight, composition will be measured through Bodpod scans. Resting metabolic rate and thermogenesis will be measured by indirect calorimetry. Also, fecal samples will be collected for gut microbiome profiling along with blood for glucose, insulin, hormones, triacylglycerol, HbA1c, short-chain fatty acid, red blood cells and FGF21. Urine samples will be collected throughout the study. A followup session at 16 weeks will reassess previous measures.

Conditions

• Overweight or Obesity
• Body Weight

Interventions

Type	Name	Description
OTHER	Dairy-based commercially available food products	Full-fat milk (3.25% milk, 250 mL), assortment of yogurts, and cheeses
OTHER	Restrictive Eating	Dietitian will assist with 500 kcal/day reduction through limiting of macronutrients 45-65% energy from carbohydrates 20-35% energy from fat 10-35% energy from protein

Timeline

• Start date: 2020-09-01
• Primary completion: 2023-09-30
• Completion: 2025-12-30
• First posted: 2020-05-22
• Last updated: 2025-03-28

Locations

2 sites across 1 country: Canada