Trials / Completed
CompletedNCT04399213
Dermal Blood Flow Response to Escalating Doses of Histamine, Administered by a Skin Prick
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 13 (actual)
- Sponsor
- Universitaire Ziekenhuizen KU Leuven · Academic / Other
- Sex
- Male
- Age
- 18 Years – 45 Years
- Healthy volunteers
- Accepted
Summary
To determine the effective dose and the time course, the dermal blood flow response to histamine will be evaluated at different doses (5 µg, 15 µg and 50 µg). Histamine will be administered by a skin prick on the volar surface of subjects' forearm, alongside a negative control. Changes in dermal blood flow will be measured with laser Doppler imaging at different time points following the skin prick.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | 50 µg Histamine | Skin prick through 50 µg/5 µL histamine diHCl |
| PROCEDURE | 15 µg Histamine | Skin prick through 15 µg/5 µL histamine diHCl |
| PROCEDURE | 5 µg Histamine | Skin prick through 5 µg/5 µL histamine diHCl |
| PROCEDURE | Placebo (saline) | Skin prick through 5 µL saline (0.9% NaCl) |
Timeline
- Start date
- 2019-01-15
- Primary completion
- 2019-02-19
- Completion
- 2019-02-19
- First posted
- 2020-05-22
- Last updated
- 2020-05-27
Locations
1 site across 1 country: Belgium
Source: ClinicalTrials.gov record NCT04399213. Inclusion in this directory is not an endorsement.