NCT04396587

Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone

Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone in Female Patients Before Anesthesia Induction

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Peking University People's Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to investigate Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone in female patients. Methods: A total of 60 patients were randomly divided into 4 groups, with 20 patients in each group. Sufentanil(0.1μg/kg), Hydromorphone(20μg/kg), or Oxycodone(60μg/kg) ,saline(10ml)was administered before anesthesia induction. Bispectral Index (BIS), Respiratory rate(RR), other non-analgesic effects at Tb (entering room), T0 (drug administration), T1 (2min), T2 (4min), T3(6min), T4(8min), T5(10min), T6(20min) were recorded.

Conditions

• Opioid Use

Interventions

Type	Name	Description
DRUG	Sufentanil	Sufentanil(0.1μg/kg) was administered before anesthesia induction.
DRUG	Hydromorphone	Hydromorphone(20μg/kg)was administered before anesthesia induction.
DRUG	Oxycodone	Oxycodone(60μg/kg) was administered before anesthesia induction.
DRUG	normal Saline	normal saline 10ml

Timeline

• Start date: 2020-05-20
• Primary completion: 2023-01-01
• Completion: 2023-06-01
• First posted: 2020-05-20
• Last updated: 2024-05-30

Locations

1 site across 1 country: China