NCT04387097

Drip-infusion of Remifentanil for RIH

Postoperative Drip-infusion of Remifentanil for Preventing Remifentanil-induced Hyperalgesia- a Retrospective Observative Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 559 (actual)
• Sponsor: Tri-Service General Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The development of remifentanil-induced hyperalgesia (RIH) is an unpleasant experience for surgical patients. An alternative management, gradual withdrawal of remifentanil was effective in prevention of RIH. The investigators designed a simple modality to assess if under withdrawal of remifentanil and further drip-infusion of remifentanil immediately after extubation affected postoperative pain score, the requirement of rescue analgesics, and adverse effects.

Detailed description

In clinical practice, the gradual withdrawal of remifentanil during surgery is unsatisfied. Thus, the investigators conducted a simple modality in a single center retrospective cohort study to assess how under baseline gradual withdrawal of remifentanil and further drip infusion of remifentanil immediately after extubation affected postoperative pain score and use of analgesics.

Conditions

• Hyperalgesia

Interventions

Type	Name	Description
DRUG	remifentanil	postoperative drip-infusion of remifentanil

Timeline

• Start date: 2018-05-01
• Primary completion: 2019-01-31
• Completion: 2019-07-22
• First posted: 2020-05-13
• Last updated: 2020-05-15

Locations

1 site across 1 country: Taiwan