Clinical Trials Directory

Trials / Completed

CompletedNCT04369950

Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine

Status
Completed
Phase
Phase 4
Study type
Interventional
Enrollment
44 (actual)
Sponsor
The University of Texas Health Science Center, Houston · Academic / Other
Sex
Female
Age
18 Years – 50 Years
Healthy volunteers
Not accepted

Summary

The purpose of this study is to show that the effect of 3% 2-chloroprocaine prior to epidural morphine administration will be not inferior to the effect of epidural 2% lidocaine with 1:200,000 epinephrine on total opioid use for 24h

Conditions

Interventions

TypeNameDescription
DRUG2% lidocaine with 1:200,000 epinephrine and epidural morphineEpidurals will be dosed with 2% lidocaine with 1:200,000 epinephrine to T4 level in 5ml increments, epidural morphine 3mg will be given after delivery of neonate. T4 level maintained throughout cesarean delivery with additional epidural doses of 2% lidocaine with 1:200,000 epinephrine for both groups. Post-operative orders of scheduled acetaminophen and ibuprofen, and oxycodone as needed will be written.
DRUG3% 2-chloroprocaine and epidural morphineEpidurals will be dosed with 3% 2-chloroprocaine to T4 level in 5ml increments, epidural morphine 3mg will be given after delivery of neonate. T4 level maintained throughout cesarean delivery with additional epidural doses of 2% lidocaine with 1:200,000 epinephrine for both groups. This is the critical component to bridge the latency period between the offset of 3% 2-chloroprocaine and the peak action of epidural morphine.Post-operative orders of scheduled acetaminophen and ibuprofen, and oxycodone as needed will be written.

Timeline

Start date
2020-05-11
Primary completion
2021-05-11
Completion
2021-07-11
First posted
2020-04-30
Last updated
2022-05-26
Results posted
2022-05-26

Locations

1 site across 1 country: United States

Regulatory

Source: ClinicalTrials.gov record NCT04369950. Inclusion in this directory is not an endorsement.