NCT04369105

Prono Position and Mechanical Power

Influence of the Prone Position on Mechanical Power Applied to Respiratory System: Multi-centric Descriptive Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 45 (actual)
• Sponsor: Sanatorio Anchorena San Martin · Academic / Other
• Sex: All
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The primary objective of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning while mantaining the same ventilatory setting. The secondary objetive of the study is to compare the mechanical power applied to the respiratory system in patient with acute respiratory distress syndrome in supine positioning and after the implementation of prone positioning and adjusting an individualized ventilatory setting.

Detailed description

Data of mechanical power will be collected prospectively in three different times: 1. In supine positioning (T0). 2. After 15 minutes of having implemented prone positioning while maintaining the same ventilatory settings that in supine (T1). 3. In prone positioning after 15 min of having adjusted an individualized ventilatory setting (T2). Besides, the investigators will take an arterial blood sample in T0 and T2 to calculate changes in oxygenation status and ventilatory ratio. In case that esophageal manometry is available, the investigators will collect data regarding to transpulmonary and esophageal pressure in order to calculate the mechanical power applied to the lung parenchyma.

Conditions

• Acute Respiratory Distress Syndrome

Interventions

Type	Name	Description
OTHER	Prone position	The patients will be put in prone position while receiving invasive mechanical ventilation and the investigators will monitor changes in mechanical power applied to the respiratory system and compare with supine position

Timeline

• Start date: 2020-05-01
• Primary completion: 2021-09-28
• Completion: 2021-09-28
• First posted: 2020-04-30
• Last updated: 2021-09-30

Locations

1 site across 1 country: Argentina