NCT04359251

Different PEEP Settings of COVID-19 Induced ARDS

Avoiding High PEEP in COVID-19 Induced ARDS: a Multi-center Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Southeast University, China · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2\<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.

Detailed description

After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.

Conditions

• COVID-19
• Mechanical Ventilation Pressure High
• Acute Respiratory Distress Syndrome

Interventions

Type	Name	Description
OTHER	Gas exchanges at different PEEP	Gas exchanges measurement at different PEEP
OTHER	lung mechanics at different PEEP	lung mechanics measurement at different PEEP
OTHER	Hemodynamics changes at different PEEP	Hemodynamics changes measurement at different PEEP

Timeline

• Start date: 2020-03-05
• Primary completion: 2020-03-25
• Completion: 2020-03-25
• First posted: 2020-04-24
• Last updated: 2020-04-24

Locations

1 site across 1 country: China