NCT04344886

Optimization and Individualization of Diagnostic Scintigraphy Protocol and Minimally Invasive Radio-guided Parathyroid Surgery

Optimization and Individualization of Diagnostic Scintigraphy Protocol and Minimally Invasive Radio-guided Parathyroid Surgery Using Quantitative Analysis of Scintigraphy Results on Hybrid SPECT-CT Imaging

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: University Hospital Ostrava · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The radio-guided technique offers both help with in-vivo identification and ex-vivo confirmation of parathyroid adenoma. In-vivo accuracy is most important but its results are not satisfactory. The aim of this study was to evaluate if there is a beneficial effect of individualized timing of surgery using preoperative multi-phase 99mTc-MIBI single-photon emission computed tomography (SPECT)/CT on in-vivo characteristics of minimally invasive radio-guided parathyroidectomy.

Detailed description

Despite the relatively accurate preoperative topographic information, minimally invasive parathyroid surgery can still be very challenging, especially in the case of small adenoma in ectopic localization. Radioguided technique offers both help with in-vivo identification and ex-vivo confirmation of adenoma. Excellent ex-vivo radio guidance results are referred. But, in-vivo accuracy is most important but its results are not satisfactory. The aim of this study was to evaluate if there is a beneficial effect of individualized timing of surgery using preoperative multi-phase 99mTc-MIBI single-photon emission computed tomography (SPECT)/CT on in-vivo characteristics of minimally invasive radio-guided parathyroidectomy.

Conditions

• Primary Hyperparathyroidism
• Thyroid Disease
• Parathyroid Diseases
• Parathyroid Adenoma

Interventions

Type	Name	Description
PROCEDURE	Conventional (dual-phase) SPECT/CT	Conventional (dual-phase) SPECT/CT (after 10 and 150 minutes)
PROCEDURE	Multi-phase SPECT/CT	Multi-phase SPECT/CT (after 10, 90, 150, 210 minutes)
PROCEDURE	Conventional minimally-invasive radio-guided parathyroidectomy	Conventional minimally invasive radio-guided parathyroidectomy in a time span of 2-3 hours from radionuclide administration
PROCEDURE	Individualised minimally-invasive radio-guided parathyroidectomy	Individualized minimally-invasive radio-guided parathyroidectomy performed in a recommended time span based on standardized uptake value calculation.

Timeline

• Start date: 2016-05-01
• Primary completion: 2020-11-30
• Completion: 2020-12-31
• First posted: 2020-04-14
• Last updated: 2022-12-07

Locations

1 site across 1 country: Czechia