NCT04344470

Study of Volition: Behavioral Analysis and Clinical Neurophysiological Analysis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 39 (actual)
• Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) · NIH
• Sex: All
• Age: 25 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Background: 'Free will' can be defined as the belief that people have control over their thoughts and movements. The topic of free will is controversial and is still being debated. Science has only partial answers to questions about free will, so researchers want to learn more about it. They want to assess the role of consciousness when intentions are present with behavior. This could help to explain the causal role of consciousness in movement or decisions. Objective: To learn more about free will. Eligibility: Healthy, right-handed adults ages 25-45 Design: Participants will be screened with medical history, physical exam, and neurological exam. Participants will have 1 study visit. It will last up to 4 hours. Participants will sit in a comfortable chair in front of a screen. They will perform some or all of the following tasks. Visual Task. Participants will watch different stimuli on the screen and answer simple questions. Electroencephalography (EEG). An EEG records the electrical activity of the brain ('brain waves'). For the EEG, small electrodes are put on the scalp with an electrode cap. A gel is placed in the space between the electrodes and the scalp. Participants' brain waves will be recorded, including while they decide whether to move their thumb. Choice/Reaction Time Task. Participants will watch different stimuli on the screen and react to them by moving their wrist. During this task, they will wear an EEG cap on their head and electrodes on their arms and wrists. Electromyography. Small electrodes will be attached to participants' skin. Their muscle activity will be recorded while they decide whether to move their wrist and during the movement itself. Transcranial Magnetic Stimulation (TMS): TMS is a non-invasive brain stimulation that uses magnetic field to stimulate nerve cells in your brain. TMS can increase or decrease brain activity in particular area of your brain. TMS operates completely outside of the body and is generally very well tolerated....

Detailed description

Study Description: The main focus of this protocol will be to try to identify the quale of free will, its electrophysiological correlates, and to determine whether this quale plays a causative role in movement. Objectives: Primary Objectives: We will be doing a series of experiments. In the first experiments, we want to explore the behavioral response of normal subjects when they move after a visual stimulus that can be seen or unseen. We want to study behavior in different conditions with movement triggered by stimuli that are seen and not seen. Furthermore, we want to analyze the EEG related to those stimuli to explore sensory and motor processing. Endpoints: Primary Endpoints: Reaction time and accuracies of the responses to different stimuli in different conditions will be identified as well as the subjects subjective experiences. EEG ERP shapes and microstates patterns will also be investigated. Study Population: Up to 50 healthy volunteers of both genders between the ages of 25-45, fluent in English and right-handed. Participant Duration: The total study is expected to last 48 months, with each individual expected to participate in a single 4-hour outpatient visit at the NIH Clinical Center, but there can be multiple visits.

Conditions

• Normal Physiology

Interventions

Type	Name	Description
DEVICE	EMG	EMG will be recorded from two electrodes placed on both extensor carpi radialis (ECR) muscles
DEVICE	EEG	EEG electrodes will be positioned according to 10-20 International System, with every impedance kept under 5 kOhm. EEG data will be amplified, filtered (DC-100 Hz), digitized at 1000 Hz, and stored on a computer for offline analysis.

Timeline

• Start date: 2020-12-22
• Primary completion: 2023-06-26
• Completion: 2024-03-21
• First posted: 2020-04-14
• Last updated: 2024-04-05

Locations

1 site across 1 country: United States