NCT04342130

Brain Effects of Opiate Agonist and Antagonist

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: University of Rochester · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study will look at the short-term effect of morphine on brain response to food.

Detailed description

Chronic low back pain patients and healthy controls will be recruited for this study. Participants' brain will be scanned at baseline and then again on a different day after the administration of an oral dose of 30 mg morphine in an open label design. Participants will receive morphine 60 minutes prior to the start of the second scanning session. The brain scans will include structural scans, functional scans at rest and functional scans during the ingestion of a highly caloric drink.

Conditions

• Chronic Low-back Pain

Interventions

Type	Name	Description
DRUG	Morphine	30 mg oral tablet

Timeline

• Start date: 2018-04-27
• Primary completion: 2019-04-16
• Completion: 2019-04-16
• First posted: 2020-04-10
• Last updated: 2021-05-07
• Results posted: 2021-05-07

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study