NCT04332809

A Randomized Controlled Trial on Wound Irrigation in Open Appendectomy.

A Randomized Controlled Trial on Irrigation of Open Appendectomy Wound With Gentamicin- Saline Solution Versus Saline Solution for Prevention of Surgical Site Infection.

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 208 (estimated)
• Sponsor: Mansoura University · Academic / Other
• Sex: All
• Age: 16 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

A large retrospective study compared wound irrigation with antiseptic solution, with antimicrobial agent, and with normal saline in patients undergoing open appendectomy and concluded an evident superiority of antibiotic wound irrigation over both normal saline and antiseptic solution. The present trial aimed to assess the efficacy of layer-by-layer wound irrigation with gentamicin-saline solution versus saline solution in prevention of incisional SSI after open appendectomy for acute appendicitis. We postulated that irrigation of every layer of the surgical wound separately would help reduce the incidence of incisional SSI by eradication of bacterial contamination of each layer which may occur during delivery, manipulation, and removal of the inflamed appendix through the McBurney's incision.

Conditions

• Appendicitis

Interventions

Type	Name	Description
PROCEDURE	saline-gentamicin irrigation	Layer-by-layer irrigation of the appendectomy wound will be performed using saline-gentamicin solution
PROCEDURE	saline irrigation	Layer-by-layer irrigation of the appendectomy wound will be performed using saline solution

Timeline

• Start date: 2019-01-01
• Primary completion: 2020-03-31
• Completion: 2020-04-30
• First posted: 2020-04-03
• Last updated: 2020-04-03

Locations

1 site across 1 country: Egypt