NCT04327492

Hemathologic and Imagiologic Predictors of Stroke During Carotid Endarterectomy With Regional Anesthesia

Clinical, Hematological, and Imagiologic Predictors of Postoperative Complications and Long Term Cardiovascular Events After Carotid Endarterectomy With Regional Anesthesia

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 272 (estimated)
• Sponsor: Universidade do Porto · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: —

Summary

Establish and validate biomarkers which improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization, outperform existing biomarkers, and reach clinical application standards.

Detailed description

The authors hypothesize FGF-23 and GDF-15 could predict cerebral ischemia, postoperative complications and long term major cardiovascular events, particularly in patients developing symptomatic neurologic ischemia after circulation shutdown. Establish and validate biomarkers which improve the predictive value of current risk stratification models for patients benefiting from carotid revascularization, outperform existing biomarkers, and reach clinical application standards. Clarify the pathophysiology of carotid endarterectomy-related stroke and the role of GDF-15, FGF-23, BNP and hs-troponin I and other biomarkers in the prognosis of symptomatic carotid stenosis. Imagiologic markers are to be included - intima-media; gray weale plaque classification, cerebral CT Peak wave velocity

Conditions

• Carotid Stenosis
• Carotid Endarterectomy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Biomarker - FGF 23; troponin I; PCR - high sensitivity; BNP	peak wave velocity; gray weale plaque classification

Timeline

• Start date: 2020-04-01
• Primary completion: 2021-12-31
• Completion: 2022-12-31
• First posted: 2020-03-31
• Last updated: 2020-03-31

Locations

1 site across 1 country: Portugal