NCT04326244

The Relationship Between Obesity-related Molecular Typing and Traditional Chinese Medicine Constitution

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Chang Gung Memorial Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Obesity is an epidemic and a growing problem in the world. There are numerous causes of obesity, the most novel and personalized of which is genetic inheritance. Single nucleotide polymorphisms are the most common type of genetic variation among people, regulating the response between the diet and the body. Meanwhile, Traditional Chinese medicine pattern differentiation is also personalized and usually influenced by inheritance, living habits, character and environment and so on. The common constitutions in obesity are Qi deficiency, Yang Deficiency, and Phlegm dampness, which are correlated with oxygen, sugar and fat metabolism, also affected by gene expression. Therefore, the relationship between constitution, metabolism and genetic molecular typing may be significant in obesity with obstructive sleep apnea patients.

Detailed description

Method The adults whose age between 20\~65 years old, BMI between 27kg/m² and 35kg/m², and also have snoring during sleeping are able to be enrolled in the study. Then, the general data questionnaire, Body Constitution Questionnaire, physical examination, blood test, and genetic test are provided to subjects. The blood test includes High-density lipoprotein- cholesterol, Low-density lipoprotein- cholesterol, Total cholesterol, Triglyceride, Leptin, Glucose AC, Hemoglobin A1C, Insulin; the DNA test includes FTO、MC4R、BDNF、PPARG、ADRB3、UCP1. Epworth Sleepiness Scale, laryngoscope and polysomnography are also performed in the patients enrolled. The Traditional Chinese medicine constitution can be classified and its relationship between different figure types, serum lipid level as well as obesity-related gene can be analyzed. The results will be described after a statistical analysis. Aim The aim of this study is to analyze the constitution, finding the association between obesity patients with obstructive sleep apnea and their related molecular typing and Traditional Chinese Medicine constitution.

Conditions

• Obstructive Sleep Apnea
• Obesity

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	blood test	High-density lipoprotein- cholesterol, Low-density lipoprotein- cholesterol, Total cholesterol, Triglyceride, Leptin, Glucose AC, Hemoglobin A1C, Insulin
DIAGNOSTIC_TEST	genetic test	FTO、MC4R、BDNF、PPARG、ADRB3、UCP1
DIAGNOSTIC_TEST	Constitution in Chinese Medicine Questionnaire	Constitution in Chinese Medicine Questionnaire
DIAGNOSTIC_TEST	Epworth Sleepiness Scale	Epworth Sleepiness Scale
DIAGNOSTIC_TEST	cephalometry	Evaluation of craniofacial morphology in OSA patients
DIAGNOSTIC_TEST	polysomnography	to evaluate Apnea-Hypopnea Index (AHI) for the severity of sleep apnea

Timeline

• Start date: 2020-04-10
• Primary completion: 2020-12-31
• Completion: 2020-12-31
• First posted: 2020-03-30
• Last updated: 2020-07-15

Locations

1 site across 1 country: Taiwan