NCT04322877

Cardiac Resynchronisation Therapy In Patients With Heart Failure: Mechanistic Insights From Cardiac MRI And Electroanatomical Mapping

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Guy's and St Thomas' NHS Foundation Trust · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Cardiac Resynchronisation Therapy (CRT) is a specialist pacemaker procedure that aims to improve the efficiency of the heartbeat. This treatment is used routinely in patients with heart failure and a delay in electrical conduction across the heart seen on the surface ECG (heart tracing). The investigators aim to assess acute response to CRT and compare different methods of delivering CRT using hemodynamic data from invasive dP/dTmax and electroanatomical data from either invasive mapping or non-invasive body surface mapping.

Conditions

• Heart Failure

Interventions

Type	Name	Description
PROCEDURE	Temporary pacing Study	Temporary delivery of CRT
RADIATION	Thoracic CT	As part of non-invasive mapping protocol
DIAGNOSTIC_TEST	Acute hemodynamic study	Measurement of invasive dP/dTmax
DIAGNOSTIC_TEST	Non-invasive body surface mapping	Cardioinsight body surface mapping
DIAGNOSTIC_TEST	Invasive catheter-based mapping	Invasive electroanatomical mapping

Timeline

• Start date: 2019-09-01
• Primary completion: 2021-09-30
• Completion: 2021-09-30
• First posted: 2020-03-26
• Last updated: 2020-03-30

Locations

1 site across 1 country: United Kingdom