NCT04321746

The Effect of Ketamine on Postoperative Cognitive Dysfunction.

The Effect of Ketamine on Postoperative Cognitive Dysfunction in Geriatric Patients Undergoing Orthopaedic Surgery Under Spinal Anaesthesia, a Randomized Controlled Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 45 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Not accepted

Summary

Available evidence suggests that there is no significant difference in the incidence of postoperative cognitive dysfunction POCD when general anaesthesia and regional anaesthesia are compared\[13, 14\]. To the knowledge of the investigators , no studies are examining the effects of ketamine on cognitive outcomes in the setting of spinal anesthesia. Thus, the purpose of this study was to compare the cognitive status, as assessed by the SPMSQ, of elderly patients undergoing orthopaedic surgery under spinal anaesthesia before and after ketamine administration. The authors hypothesized that patients receiving ketamine would exhibit better cognitive performance.

Conditions

• Postoperative Cognitive Dysfunction

Interventions

Type	Name	Description
DRUG	Ketamine	ketamine will be administered at a dose of 0.3 mg/kg in normal saline at 0.9% (250 mL)
OTHER	Placebo	the control group will receive only normal saline at 0.9%, with the same physical characteristics of the ketamine solution

Timeline

• Start date: 2020-12-10
• Primary completion: 2022-03-08
• Completion: 2022-03-09
• First posted: 2020-03-25
• Last updated: 2022-05-10

Locations

1 site across 1 country: Egypt