NCT04320368

China Alzheimer's and Neurodegenerative Disorder Research

China National Clinical Research Center Alzheimer's Disease and Neurodegenerative Disorder Research

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 3,100 (estimated)
• Sponsor: Beijing Tiantan Hospital · Academic / Other
• Sex: All
• Age: 40 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

This is a multi-center study that has three cohorts: 1) cognitive normal cohort (CN), 2) Alzheimer's disease cohort (AD) and 3) vascular cognitive impairment cohort (VCI). The goal of this study is to understand the risk factors of AD and VCI and to identify high risk patients for early intervention. It will collect demographic information, family history, medical history, neuropsychological tests, imaging studies and biological samples through standard and uniform procedures.

Detailed description

In this prospective study, we will recruit subjects into one of the three groups based on inclusion and exclusion criteria: 1) CN, 2) AD and 3) VCI. We will follow up with each of them subject at designated time points up to 2 years. We will collect demographic, medical, imaging (MRI and PET scans), genetic information and various biological samples (blood, saliva, urine and feces) during the study period. This study uses a case-control study design. The matched cases will have similar age, gender and education levels. By studying the relationship between risk factors of AD and VCI, we will establish norms and parameters in the Chinese population.

Conditions

• Cognitive Impairment

Timeline

• Start date: 2019-07-08
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2020-03-25
• Last updated: 2023-08-08

Locations

1 site across 1 country: China