NCT04310241

Visual Function Abnormalities in Strabismus and Amblyopia and Response to Therapy

Oculomotor Disorders: Experimental and Clinical Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: The Cleveland Clinic · Academic / Other
• Sex: All
• Age: 6 Months – 90 Years
• Healthy volunteers: Not accepted

Summary

Amblyopia and strabismus are characterized by a reduction in visual acuity, contrast sensitivity, grating acuity, vernier acuity, reading difficulties and binocular visual function deficits. Treated patients have residual visual function deficits. The purpose of the current study is to quantify various visual functions in amblyopic and strabismic participants at baseline, during and at the completion of treatment.

Detailed description

To examine the response of therapy on visual functions in amblyopic and strabismic participants. The following visual functions will be measured prior to treatment. Eye movements, contrast sensitivity, grating acuity, visual acuity, vernier acuity, binocular visual functions, reading and visual scanning will be measured. The testing will comprise of one or more of the above paradigms depending on participant's cooperation and understanding as majority of the study participants will be children. The above measurements will be repeated during amblyopia therapy ( which comprises of glasses, patching and/or atropine eye drops) and at the completion of treatment. For participants with strabismus requiring strabismus surgery the measurements will be repeated after strabismus surgery.

Conditions

• Amblyopia
• Strabismus

Interventions

Type	Name	Description
BEHAVIORAL	Patching therapy, Glasses	Patching, glasses and strabismus surgery are commonly employed measures in treatment of amblyopia and strabismus.

Timeline

• Start date: 2020-02-21
• Primary completion: 2027-03-12
• Completion: 2027-03-12
• First posted: 2020-03-17
• Last updated: 2026-03-04

Locations

1 site across 1 country: United States