NCT04300933

Neurofeedback Intervention for Preclinical Alzheimer's Disease

Effects of Electroencephalogram-based Neurofeedback on Cognition in Adults With Subject Cognitive Decline

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: XuanwuH 2 · Academic / Other
• Sex: All
• Age: 50 Years – 79 Years
• Healthy volunteers: Not accepted

Summary

Alzheimer's disease (AD) is the most common form of neurodegenerative disorders leading to dementia. Currently, there has been no effective pharmacologic therapy for this disease. Electroencephalogram-based neurofeedback is considered as a potentially treatment strategy. In this project, the investigators aim to investigate the effectiveness of neurofeedback therapy on cognition for individuals with subjective cognitive decline (SCD). Participants will receive electroencephalogram-based neurofeedback therapy once a day for successive five days. Then, the investigators will evaluate the changes of memory function between baseline and post-therapy visits.

Detailed description

Currently, there has been no effective therapy for Alzheimer's disease (AD). Electroencephalogram-based neurofeedback is now considered as a potentially intervention and may positively affect cognitive function for patients with AD. However, there are few existing studies involving the role of neurofeedback on cognition for subjective cognitive decline (SCD). Fifty participants with SCD will be recruited in this clinical trial. At baseline, neuropsychological tests are conducted. Participants will receive electroencephalogram-based neurofeedback therapy once a day for successive five days. After that, the investigators will evaluate the changes of memory measures, which is the primary outcome.

Conditions

• Alzheimer Disease
• Subjective Cognitive Decline
• Neurofeedback
• Electroencephalogram

Interventions

Type	Name	Description
BEHAVIORAL	Electroencephalogram-based neurofeedback	In this project, SCD participants will receive electroencephalogram-based neurofeedback therapy, once a day, for 5 days. Then, the investigators will compare their memory changes between baseline and post-therapy visits.

Timeline

• Start date: 2019-04-01
• Primary completion: 2019-08-01
• Completion: 2019-12-31
• First posted: 2020-03-09
• Last updated: 2020-03-09

Locations

1 site across 1 country: China