NCT04299477

THE EFFETCS OF NON-SURGICAL PERIODONTAL TREATMENT ON SALIVARY BIOMARKERS OF PATIENTS WITH OSTEOPOROSIS AND PERIODONTITIS

EVALUATION OF THE EFFETCS OF NON-SURGICAL PERIODONTAL TREATMENT ON SALIVARY BIOMARKERS OF PATIENTS UNDERGOING BISPHOSPHONATE THERAPY

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 75 (actual)
• Sponsor: Gazi University · Academic / Other
• Sex: Female
• Age: 35 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Inflammatory mediators in periodontitis may lead to elevated systemic cytokine levels, resulting in increased bone resorption including the jaws. Osteoporosis may have an influence on the periodontal condition of post-menopausal women and the risk for periodontal disease may increase due to osteoporosis. The hypothesis of the study was that non-surgical periodontal treatment and medical treatment of osteoporosis by bisphosphonates may improve the clinical outcomes and decrease salivary levels of IL-1β, IL-17, ALP and 8-OHdG. Therefore, the aim of this study was to evaluate the mechanism of bi-directional relationship between osteoporosis and periodontal diseases and to investigate the outcomes of non-surgical periodontal treatment with regard to salivary levels of IL-1β, IL-17, 8-OHdG and ALP in patients with periodontitis and osteoporosis.

Conditions

• Osteoporosis
• Periodontitis

Interventions

Type	Name	Description
PROCEDURE	non-surgical periodontal treatment	supra- and subgingival scaling, and root planning

Timeline

• Start date: 2018-06-30
• Primary completion: 2019-03-30
• Completion: 2019-05-30
• First posted: 2020-03-06
• Last updated: 2020-03-06

Locations

1 site across 1 country: Turkey (Türkiye)