Trials / Completed
CompletedNCT04292977
Splanchnic and Systemic VLDL-TG and FFA Balance
Splanchnic and Systemic VLDL-TG and FFA Balance in Individuals With NAFL and NASH
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 17 (actual)
- Sponsor
- University of Aarhus · Academic / Other
- Sex
- Male
- Age
- 40 Years – 70 Years
- Healthy volunteers
- Accepted
Summary
To determine differences between NAFLD and NASH subjects with respect to hepatic FA metabolism (uptake, oxidation, and re-esterification) and hepatic VLDL-TG secretion and peripheral kinetics (oxidation and tissue storage). 8 non-diabetic upper-body obese subjects with NAFLD and 8 with NASH (biopsy proven) will be studied in the overnight fasted state. VLDL-TG stable isotope will be used in combination with hepatic vein catherization to directly measure splanchnic VLDL-TG uptake and secretion. FFA (palmitate) tracers as well as adipose tissue and skeletal muscle biopsies will be used to measure whole-body substrate turnover and flexibility as well as tissue specific substrate handling during fasting and hyperinsulinemic conditions.
Conditions
Timeline
- Start date
- 2018-12-01
- Primary completion
- 2020-11-15
- Completion
- 2022-05-01
- First posted
- 2020-03-03
- Last updated
- 2022-05-24
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT04292977. Inclusion in this directory is not an endorsement.