NCT04292483

Pulmonary Capillary Recruitment in Fontan Patients

Pulmonary Capillary Recruitment With Pulmonary Vasodilator Therapy in Patients With Univentricular Heart Physiology and Failing Total Cavo-pulmonary Connection.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 15 (estimated)
• Sponsor: Jewish General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates the effects of pulmonary vasodilator therapy on pulmonary capillary blood flow by measuring the functional capillary surface area (FCSA) at baseline and post nitric oxide inhalation, through the injection of 3H-benzoyl-Phe-Ala-Pro (BPAP). FCSA will be related to flow and other hemodynamic parameters in order to determine if there is capillary recruitment or distention in Fontan patients. We will also compare baseline FCSA measurements with previously studied normal subjects, to assess the difference in hemodynamic pulmonary functional parameters between these single ventricle physiology patients and normal subjects.

Conditions

• Congenital Heart Disease

Interventions

Type	Name	Description
DRUG	Nitric Oxide	Inhaled vasodilator to increase pulmonary capillary perfusion

Timeline

• Start date: 2020-06-11
• Primary completion: 2023-12-31
• Completion: 2023-12-31
• First posted: 2020-03-03
• Last updated: 2022-04-07

Locations

1 site across 1 country: Canada