NCT04280354

Molecular Biomarkers for Sepsis

Prospective Study to Discover New Biomarkers for Early Detection of Sepsis and Prediction of Sepsis-related Mortality in Patients With Severe Community Acquired Pneumonia (sCAP)

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 3 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This multi-center observational case-control study in Intensive Care Unit (ICU) patients is to identify novel biomarkers allowing to recognize severe community acquired pneumonia (sCAP) -associated sepsis at an earlier stage and predict sepsis-related mortality. Patients with sCAP (cases) will be profoundly characterized over time regarding the development of sepsis and compared with control patients. The mechanisms and influencing factors on the clinical course will be explored with most modern -omics technologies allowing a detailed characterisation. These data will be analysed using machine learning algorithms and multi-dimensional mathematical models.

Conditions

• Sepsis
• Severe Community-acquired Pneumonia (sCAP)
• Infection, Bacterial

Interventions

Type	Name	Description
OTHER	compare data patterns by data-driven algorithms to determine sepsis	compare data patterns by data-driven algorithms including machine learning and multi-dimensional modelling to reliably determine sepsis
OTHER	compare data patterns by data-driven algorithms to predict sepsis-related mortality	compare data patterns by data-driven algorithms including machine learning and multi-dimensional modelling to to predict sepsis-related mortality

Timeline

• Start date: 2022-02-16
• Primary completion: 2022-07-31
• Completion: 2022-07-31
• First posted: 2020-02-21
• Last updated: 2024-05-09

Locations

15 sites across 1 country: Switzerland