NCT04277728

Hypoperfusion-hypodensity Mismatch for the Identification of Patients With Stroke Within 4.5 Hours

Mismatch Between Hypoperfusion and Hypodensity on CT for the Identification of Patients With Stroke Onset Within 4.5 Hours

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 689 (actual)
• Sponsor: University Hospital Muenster · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Intravenous thrombolysis is recommended within 4.5 hours of stroke onset. The aim of the study is to evaluate whether a hypodensity on native CT within the virtually entire area of hypoperfusion on perfusion CT, i.e. hypoperfusion-hypodensity mismatch, identifies patients within the time window of thrombolysis in a multicenter cohort. The investigators hypothesize hypoperfusion-hypodensity mismatch will identify patients ≤ 4,5 hours of symptom onset with \>70% specificity and \>85% positive predictive value.

Conditions

• Acute Ischemic Stroke

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	hypoperfusion-hypodensity mismatch	hypoperfusion-hypodensity mismatch on computed tomography

Timeline

• Start date: 2018-01-01
• Primary completion: 2019-12-31
• Completion: 2019-12-31
• First posted: 2020-02-20
• Last updated: 2020-02-20

Locations

1 site across 1 country: Germany