NCT04263415

The Effects of Semaglutide on Taste, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Response in Women With PCOS and Obesity

The Effects of Semaglutide on Modulation of Taste Sensitivity, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Responses in Women With PCOS and Obesity: a Randomized, Single-blind, Placebo-controlled Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University Medical Centre Ljubljana · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to explore the effects of GLP-1 receptor agonist (GLP-1 RA) semaglutide on modulation of taste sensitivity, tongue tissue transcriptome, modulation of neural response in central reward processing regions and gastric emptying rate. In addition, we aim to investigate the associations between semaglutide induced modulation of taste sensitivity, neural responses and gastric emptying with changes in body mass, eating- behavioural pattern, food perception and food intake.

Conditions

• PCOS
• Semaglutide
• Taste, Altered
• Tongue Tissue Transcriptome
• Gastric Emptying
• Central Neural Response

Interventions

Type	Name	Description
DRUG	Semaglutide	semaglutide inrun period of 4 weeks with 0.5mg/week s.c. followed by 1mg/week sc for 12 weeks
OTHER	Placebo	once-weekly injection with placebo pen for 16 weeks

Timeline

• Start date: 2019-11-02
• Primary completion: 2020-05-08
• Completion: 2021-10-31
• First posted: 2020-02-10
• Last updated: 2023-09-08

Locations

1 site across 1 country: Slovenia