NCT04263376

Bariatric Surgery-Induced Shift in Gut Microbiome and NAFLD

Can Bariatric Surgery-Induced Shift in Gut Microbiome Protect Against Non-Alcoholic Fatty Liver Disease? A Step Toward Replicating Metabolic Surgery Results Without Surgery

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 18 (actual)
• Sponsor: The Cleveland Clinic · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study is designed as a prospective pilot study for longitudinal assessment of fecal microbiome related to medical and surgical weight loss. The investigators follow the standard of care for perioperative and intraoperative management of study participants. The only addition to the standard of care protocol will be collection of fecal samples at 3 time points. This will enable investigators to compare changes in and effects by microbiota after low-calorie diet versus after bariatric surgery .

Conditions

• Obesity
• Diabetes Mellitus, Type 2
• NAFLD

Timeline

• Start date: 2019-04-24
• Primary completion: 2022-01-31
• Completion: 2022-01-31
• First posted: 2020-02-10
• Last updated: 2023-01-05

Locations

1 site across 1 country: United States