NCT04262830

Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure

CATCH-HF: Cardiotoxicity Assessment Through Comprehensive Heart Imaging to Predict Heart Failure

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Hari Narayan · Academic / Other
• Sex: All
• Age: 13 Years – 39 Years
• Healthy volunteers: Not accepted

Summary

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.

Detailed description

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies. Cardiac remodeling, function, and tissue characteristics will be examined using cardiac MRI in combination with other research assessments to assess the cardiotoxic effects of cancer therapy. Analyses will be performed in a cohort of adolescents and young adults with a history of childhood cancer.

Conditions

• Cardiotoxicity
• Pediatric Cancer
• Heart Failure

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Cardiac magnetic resonance imaging (MRI)	Cardiac magnetic resonance imaging will be performed to evaluate cardiac remodeling, function, and tissue characteristics
OTHER	Accelerometer physical activity monitoring	Measurement of physical activity using hip-worn accelerometer.

Timeline

• Start date: 2019-09-30
• Primary completion: 2028-09-30
• Completion: 2030-09-30
• First posted: 2020-02-10
• Last updated: 2025-01-28

Locations

1 site across 1 country: United States