Trials / Unknown
UnknownNCT04259567
Improvement of Cerebrovascular Autoregulation in Patients With Septic Shock Due to Cytokine Elimination
Verbesserung Einer gestörten zerebrovaskulären Autoregulation Bei Patienten im Septischen Schock Durch Extrakorporale Reduktion Von Entzündungsmediatoren
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 150 (estimated)
- Sponsor
- Johannes Gutenberg University Mainz · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The trial investigates the effect of cytokine elimination in patients with septic schock and acute renal failure with need for renal replacement therapy on the integrity of cerebrovascular autoregulation. Patients with inclusion criteria were randomly assign in either use of CytoSorb filter integrated in renal replacement therapy versus non additional filter an renal replacement therapy alone. Cerebrovascular autoregulation will be measured with transcranial Doppler ultrasound and correlation with arterial blood pressure.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Cytokine absorption | Use of CytoSorb absorber |
Timeline
- Start date
- 2020-06-08
- Primary completion
- 2021-12-31
- Completion
- 2022-07-31
- First posted
- 2020-02-06
- Last updated
- 2020-06-11
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT04259567. Inclusion in this directory is not an endorsement.