NCT04257877

Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)

Targeted Proteomic Analysis in the Plasma of Children With Diabetes Type 1 and Its Association With Peripheral Diabetic Neuropathy

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: Aristotle University Of Thessaloniki · Academic / Other
• Sex: All
• Age: 5 Years – 10 Years
• Healthy volunteers: Accepted

Summary

The aim of the present study is to investigate a targeted proteomic analysis in plasma of children - of Greek origin- with type 1 diabetes (DT1) and its correlation with the electrophysiological findings that accompany diabetic peripheral neuropathy. Diabetic neuropathy is the most frequent chronic complication in adults with DT1 and rarely appears in childhood. Nevertheless, cases of acute mononeuritis have been described at the time of diagnosis of DT1. According to recent reports several biomarkers, including proteomic analysis, have been proposed for the early detection of peripheral neuropathy in children and young adults with T1DM. In the present study the researchers will attempt to investigate the role of biomarkers with targeted proteomic analysis in the plasma of children with DT1 in combination with an electrophysiological study, which includes a nerve conduction study, to detect early diabetic peripheral neuropathy, before the appearance of clinical manifestations.

Conditions

• Diabetes Type 1
• Proteomics
• Diabetic Peripheral Neuropathy

Interventions

Type	Name	Description
PROCEDURE	Blood sampling	Blood samples for proteomic analysis in plasma of both groups

Timeline

• Start date: 2018-11-20
• Primary completion: 2025-01-20
• Completion: 2025-01-20
• First posted: 2020-02-06
• Last updated: 2024-07-31

Locations

1 site across 1 country: Greece