NCT04257201

Mushroom Ingestion Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 7 (actual)
• Sponsor: Purdue University · Academic / Other
• Sex: All
• Age: 30 Years – 69 Years
• Healthy volunteers: Accepted

Summary

The investigators propose to determine the effect of consuming 0, 1 or 2 servings of white button (Agaricus bisporus; most popular, lower ergothioneine) or yellow oyster (Pleurotus citrinopileatus; higher ergothioneine) mushrooms on postprandial changes in plasma levels and urinary excretions of mushroom-specific compounds.

Detailed description

The investigators hypothesize that consuming different mushroom varieties will elicit distinct postprandial nutrimetabolomic profiles in the plasma and urine and that the amount of metabolites present will increase with the servings of mushrooms. Measuring ergothioneine in the plasma will provide a quantitative outcome to document the postprandial responses to consuming the test meals. The nutrimetabolomic related outcomes are exploratory and have not been documented in human research.

Conditions

• Diet, Healthy

Interventions

Type	Name	Description
OTHER	Yellow Oyster -- 84 g	Participants will consume the standardized test day salad plus 84 g (raw weight) mushrooms. Mushrooms will be cooked prior to being served
OTHER	Yellow Oyster -- 168 g	Participants will consume the standardized test day salad plus 168 g (raw weight) mushrooms. Mushrooms will be cooked prior to being served
OTHER	White button -- 84 g	Participants will consume the standardized test day salad plus 84 g (raw weight) mushrooms. Mushrooms will be cooked prior to being served
OTHER	White button -- 168 g	Participants will consume the standardized test day salad plus 168 g (raw weight) mushrooms. Mushrooms will be cooked prior to being served
OTHER	Control	Participants will consume the standardized test day salad only

Timeline

• Start date: 2020-08-15
• Primary completion: 2021-05-21
• Completion: 2021-05-21
• First posted: 2020-02-05
• Last updated: 2024-02-16

Locations

1 site across 1 country: United States