Trials / Completed
CompletedNCT04239963
Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 60 (actual)
- Sponsor
- Mclean Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years – 70 Years
- Healthy volunteers
- Accepted
Summary
The overarching goal of the present study is to evaluate the effect of a subanesthetic dose of ketamine 24-hour post-injection on resting state functional connectivity, cognitive control, and reward learning.
Detailed description
Major Depressive Disorder (MDD) participants with treatment-resistant depression (TRD) will be recruited from McLean's Ketamine clinic. Suitability for Ketamine treatment will be determined as typically done by the service - through evaluation by the clinicians on the staff of the Ketamine Service who perform psychiatric consultations and assessments for Ketamine suitability. Potential subjects will be informed about the study only after they have received a positive consultation at the clinic and have already agreed to receive the treatment. This study consists of a set of questionnaires, urine drug screen, and electroencephalogram (EEG) recordings.
Conditions
Timeline
- Start date
- 2020-08-17
- Primary completion
- 2024-08-28
- Completion
- 2024-08-28
- First posted
- 2020-01-27
- Last updated
- 2024-10-30
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT04239963. Inclusion in this directory is not an endorsement.