NCT04236531

Source-monitoring & Psychosis

Source-monitoring Processes and Risk for Psychosis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Hôpital le Vinatier · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

Source-monitoring is a cognitive process that refers to the ability to remember the source of an information. Some studies have showed source-monitoring deficits in patients with schizophrenia as well as in individuals at ultra-high risk for psychosis (UHR) and in first-episode psychosis patients (FEP). Source-monitoring deficits have thus been proposed as a potential early risk factor for psychosis. However, further studies are needed to better characterize this deficit. The aim of this project is to investigate source-monitoring performances in UHR, FEP patients and healthy controls (HC) and to characterize these deficits in terms of brain anatomy, basic auditory processes and social functioning.

Detailed description

Ninety participants will be included in the study: 30 UHR, 30 FEP and 30 healthy controls. All the participants will complete a standardized source-monitoring task, an MRI acquisition (3D-T1 anatomical scan), a tone-matching task as well as a socio-demographic and clinical evaluation including an assessment of the social functioning.

Conditions

• Psychosis

Interventions

Type	Name	Description
OTHER	Cognitive tests and neuroimaging	comparison of cognitive performances and brain anatomy

Timeline

• Start date: 2021-05-17
• Primary completion: 2023-10-01
• Completion: 2024-01-01
• First posted: 2020-01-22
• Last updated: 2022-03-24

Locations

2 sites across 1 country: France