NCT04233541

Frailty Status and Increased Risk for Falls

Frailty Status and Increased Risk for Falls: The Role of Anticholinergic Burden

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 1,000 (estimated)
• Sponsor: Saglik Bilimleri Universitesi · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

We hypothesized that the use of anticholinergic medications may precipitate falls differently by frailty status in older adults. Community-dwelling older subjects admitted to the Geriatrics Outpatient Clinic prospectively enter into the study. Frailty status is defined according to the Physical Frailty Phenotype. The drugs are categorized according to the ACB scale

Detailed description

Previous studies have found that the use of drugs with anticholinergic properties relate to increased prevalence of falls in older women and men. Frailty is associated with serious health outcomes including falls, hip fractures, and death. Frailty can be a relevant target to investigate its association with the risk of falls among the users of drugs with anticholinergic properties. A recent evidence suggests that the interaction between being frail and adverse outcomes in older adults receiving polypharmacy or centrally acting drugs is complex and not straightforward across all frailty phenotypes. We classify the participants frail if they met at least three of five criteria, while those having one or two criteria were pre-frail, and others were non-frail. We determine the anticholinergic burden by using the Anticholinergic Cognitive Burden (ACB) Scale developed by Boustani et al.

Conditions

• Frailty
• Fall
• Anticholinergic Toxicity

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Fall assessment	Through a comprehensive geriatric assessment carried out by our geriatrician led multidisciplinary team we gather information about fall recalls consistent with the definition of landing on the floor or ground.

Timeline

• Start date: 2017-05-01
• Primary completion: 2020-01-31
• Completion: 2025-12-31
• First posted: 2020-01-18
• Last updated: 2020-01-18

Locations

1 site across 1 country: Turkey (Türkiye)