NCT04231617

The Hemodynamic Effects of CGRP After Glibenclamide Administration in Healthy Volunteers

The Hemodynamic Effects of CGRP After Glibenclamide Administration in a Randomized Double-blind Cross-over Placebo-controlled Study With Healthy Volunteers

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

To investigate the hemodynamic effects of CGRP after glibenclamide administration.

Detailed description

20 healthy participants will randomly be allocated to receive CGRP infusion followed by glibenclamide or placebo on two different days. The aim of the study is to investigate the vascular effect of CGRP after glibenclamide administration. Repeated measurements covering the arteria radialis (RA), superficiel temporal artery (STA) and middle cerebral artery (MCA) before and after glibenclamide/placebo administration and CGRP infusion.

Conditions

• Hemodynamics of Cranial Arteries
• Headache
• Cerebral Blood Flow

Interventions

Type	Name	Description
DRUG	glibenclamide	Oral administration of glibenclamide or placebo. To investigate the role of CGRP on cranial arteries in healthy volunteers after glibenclamide/placebo administration .
DRUG	CGRP infusion	CGRP infusion
DRUG	Placebo	placebo

Timeline

• Start date: 2020-01-20
• Primary completion: 2020-08-01
• Completion: 2020-09-01
• First posted: 2020-01-18
• Last updated: 2020-09-09

Locations

2 sites across 1 country: Denmark