NCT04218760

Multiomics After Headache Provocation of People Who Are Unable to Have Headache

Pain Perception, Headache Provocation and Multiomics of People Who Are Unable to Have Headache

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: Male
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Headaches are extremely common illnesses with a combined lifetime prevalence of 90-99% in Europe. Despite this high prevalence, there are persons who have never, in their whole life, encountered a headache. The aim of the study is to identify factors that protect against headache by studying multiomics in people who never have had a headache (headache resistant) versus non-resistant controls. The investigators will measure multiomic changes (transcriptomics and metabolomics) after headache provocation with isosorbide mononitrate. 3 blood samples, two for RNA and one for metabolomics are taken right before administration of isosorbide mononitrate, 3 hours after administration of isosorbide mononitrate and again 5 hours after administration of isosorbide mononitrate. The investigators hope to contribute with novelty to the current understanding of headache pathophysiology and development of more efficient treatment of headache.

Conditions

• Headache
• Healthy

Interventions

Type	Name	Description
DRUG	Isosorbide Mononitrate 60 MG Extended Release Oral Tablet [Imdur]	1 tablet Isosorbide Mononitrate 60 mg administrated orally.
OTHER	Blood sample	3 blood samples from a periferal vein, two for RNA and one for metabolomics are taken right before administration of isosorbide mononitrate, 3 hours after administration of isosorbide mononitrate and again 5 hours after administration of isosorbide mononitrate.

Timeline

• Start date: 2019-10-10
• Primary completion: 2020-03-12
• Completion: 2020-03-12
• First posted: 2020-01-06
• Last updated: 2021-03-25

Locations

1 site across 1 country: Denmark