NCT04218357

Probenecid as Medication for Alcohol Use Disorder (PROB)

Probenecid as Pharmacotherapy for Alcohol Use Disorder

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 35 (actual)
• Sponsor: Brown University · Academic / Other
• Sex: All
• Age: 21 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The design is a randomized, within-subject, crossover, double-blind, placebo-controlled human alcohol laboratory study with one oral dose of 2g probenecid or placebo administered in two laboratory sessions.

Detailed description

There will be a total of four study visits. Visit 1 is the screening for eligibility (medical and physical examination). On Visits 2 and 3, participants will undergo an alcohol laboratory session with a one week washout period before administering the alternate therapy. The study will conclude at Visit 4.

Conditions

• Alcohol Use Disorder

Interventions

Type	Name	Description
DRUG	Probenecid or placebo single administration	study drug administration with alcohol in the laboratory

Timeline

• Start date: 2020-12-02
• Primary completion: 2023-05-16
• Completion: 2023-05-20
• First posted: 2020-01-06
• Last updated: 2025-02-27
• Results posted: 2025-02-27

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study