NCT04204876

Longitudinal Imaging in Patients With Large Vessel Vasculitis to Predict Further Disease Course

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 40 (actual)
• Sponsor: University Hospital, Basel, Switzerland · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Longitudinal imaging in patients with large vessel vasculitis to predict further disease course

Detailed description

This explorative longitudinal prospective observational study is to explore different aspects of vessel wall characteristics as detected by magnet resonance imaging (MRI) techniques and positron emission tomography/computer tomography (PET/CT) in patients with large vessel giant cell Arteriitis (LV-GCA) for their usefulness as predictive factor for future giant cell arteritis (GCA) relapse. It analyses parameters in PET/CT and MRI in patients with GCA at treatment stop which correlate with GCA relapse within the first 6 months after treatment stop. Patients included in the established local GCA database (BARK) will be screened for eligibility. Aortal imaging is performed during routine care according to established guidelines at diagnosis and during Follow Up at least every two years and before treatment stop.

Conditions

• Giant Cell Arteritis
• Large Vessel Giant Cell Arteriitis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Magnet Resonance Imaging (MRI)	MRI with and without Gadolinium contrast agent for the following vessels: thoracic aorta (ascending, arch, descending arch, left and right common carotic, subclavian, and vertebral artery)
DIAGNOSTIC_TEST	PET/CT analysis	Standard value uptake measurement (SUV) based on quantitative score normalized to liver (SUV vessel max/liver mean) at the following vessel regions: Carotid artery: common, internal, external; Subclavian artery; Axillary artery; Vertebral artery; Thoracic Aorta; Abdominal Aorta; Common femoral artery; Deep femoral artery; Popliteal artery

Timeline

• Start date: 2020-05-28
• Primary completion: 2023-08-05
• Completion: 2023-08-05
• First posted: 2019-12-19
• Last updated: 2024-01-18

Locations

1 site across 1 country: Switzerland