NCT04204694

Study of the Role of Interferon αon the Endothelial Dysfunction During Septic Shock

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: University Hospital, Strasbourg, France · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Septic shock is the most severe form of a bacterial infection, affecting 24 million patients per year worldwide, with a high mortality (\> 30%). Septic shock is defined by an acute circulatory failure, with low blood pressure and insufficient oxygen supply to organs. This circulatory failure is related to vascular damages, in which the endothelial vascular tissue is impaired by inflammatory mechanisms, with release of circulating endothelial cells in the blood. Therefore, modulating inflammation on the vascular endothelial tissue could be a therapeutic strategy, and the investigators focus on the role of the type I interferons on the endothelial tissue because of the demonstrated role of type I interferons during septic shock. Thus the investigators proceed to an observational study, in which the primary purpose will be to show a higher expression of type I interferon receptors on circulating endothelial cells in patients with septic shock compared to control subjects. Concerning secondary purposes, the investigators will record mortality at d3, d7 and d28, perform assays about types I, II and III interferons in plasma, and test anti-interferon on endothelial cells ex vivo

Conditions

• Septic Shock

Interventions

Type	Name	Description
OTHER	3-time blood sampling for septic shock patients	15 mL blood are sampled at day1, day 3 and day 7, from the arterial catheter inserted for all patients with septic shock
OTHER	Only one blood sampling for controls patients	15 mL blood are sampled from a blood donation

Timeline

• Start date: 2020-07-01
• Primary completion: 2022-04-01
• Completion: 2023-04-01
• First posted: 2019-12-19
• Last updated: 2021-09-14

Locations

1 site across 1 country: France