NCT04201470

Serum Neurofilaments and GFAP in Atypical Multiple Sclerosis

Serum Neurofilaments Light Chain and GFAP (Glial Fibrillary Acidic Protein) in Atypical Idiopathic Inflammatory Demyelinating Disorders

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: University Hospital, Montpellier · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Idiopathic inflammatory disorders of the central nervous system include various disorders of which multiple sclerosis is the most common. Besides multiple sclerosis, other distinct disorders including for example anti-AQP4 (aquaporine-4) and anti-MOG (Myelin oligodendrocyte glycoprotein) NMOSD (Neuromyelitis optica spectrum disorder) have been well characterized and are now known to be distinct from MS. some patient belonging to MS spectrum have recently being characterized but unusual MRI findings have mimicking inherited leukoencephalopathies and leukodystrophies. Whether these patients with atypical phenotype represent a separate disease distinct from MS or belong to MS spectrum is not clear. The objectives are to evaluate a series of 15 patients with atypical forms of MS using non-conventional MRI techniques and biological biomarkers (serum neurofilaments light chain) and to compare them with classical MS patients (15 relapsing remitting patients and 15 progressive patients) and 15 controls. the hypothesize is that these patients with atypical MS have a more severe neurodegenerative process.

Conditions

• Relapsing Remitting Multiple Sclerosis
• Progressive Multiple Sclerosis
• Controls
• Multiple Sclerosis

Interventions

Type	Name	Description
OTHER	Blood withdrawal	Measurement of serum neurofilaments light chain and GFAP
OTHER	MRI	Cervical and cerebral MRI without contrast injection
OTHER	Neurologic / neuropsychologic tests - Patients	EDSS (Expanded Disability Status Scale), NHPT (Nine Hole Peg Test), T25FW (Timed 25-Foot Walk Test), 6MWT (Six-Minute Walk Test), CSCT (Computerized version of the Symbol Digit Modalities Test)
OTHER	Neurologic / neuropsychologic tests - Controls	NHPT, T25FW, CSCT

Timeline

• Start date: 2019-12-09
• Primary completion: 2022-05-23
• Completion: 2022-05-23
• First posted: 2019-12-17
• Last updated: 2025-09-30

Locations

1 site across 1 country: France