NCT04195061

Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 28 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The goal of this research study is to learn more about the hormones that muscles make during exercise, and if those hormones are associated with type 2 diabetes risk in adults who are overweight or obese. Participants will undergo exercise testing on an upright bicycle, with blood samples taken for muscle hormones before and after exercise. The hypothesis is that adults with overweight/obesity and insulin resistance will have an impaired muscle hormone profile in response to exercise compared to adults with overweight/obesity who are not insulin resistant.

Conditions

• Overweight and Obesity
• Insulin Resistance

Interventions

Type	Name	Description
PROCEDURE	Cardiopulmonary exercise test (CPET)	CPET studies will be performed in the Cardiovascular Performance Program exercise lab at MGH. Subjects will undergo CPET on an upright cycle ergometer with continual measurement of metabolic gas exchange via a commercially available metabolic cart as well as heart rate and blood pressure. Exercise will proceed according to a maximal effort clinical protocol. Subjects will then undergo a standardized 30-min work load on the upright cycle ergometer based on the results of the maximal effort clinical protocol.

Timeline

• Start date: 2019-12-12
• Primary completion: 2021-11-17
• Completion: 2021-11-17
• First posted: 2019-12-11
• Last updated: 2024-01-30
• Results posted: 2024-01-30

Locations

1 site across 1 country: United States