Trials / Completed
CompletedNCT04170738
Brain Indices of Stimulant Treatment in Drug-Naive Youth at Risk for Substance Use Disorder
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 33 (actual)
- Sponsor
- Jeffrey Newcorn · Academic / Other
- Sex
- All
- Age
- 7 Years – 12 Years
- Healthy volunteers
- Not accepted
Summary
Childhood ADHD and comorbid oppositional defiant disorder (ODD) and conduct disorder (CD) are considered risk factors for subsequent substance abuse, and youth with both ADHD and ODD/CD are at greatest risk. However, the effects of treatment of ADHD with stimulant medications such as methylphenidate (MPH) and mixed amphetamine salts (MAS) on risk for substance abuse are poorly understood. The study team propose to use fMRI to study the effects of extended release mixed amphetamine salts (MAS-XR) in drug-naïve youth 7-12 years at low risk (i.e., ADHD only) and high risk (i.e., ADHD + ODD/CD) for substance abuse on the brain reward system, to better understand the potential impact of these medications on an aspect of brain functioning which is thought to underlie vulnerability to substance abuse.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Adderall | 3 weeks of Adderall |
Timeline
- Start date
- 2019-11-05
- Primary completion
- 2023-08-08
- Completion
- 2023-08-08
- First posted
- 2019-11-20
- Last updated
- 2024-08-29
- Results posted
- 2024-08-29
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT04170738. Inclusion in this directory is not an endorsement.