NCT04170660

Interest of sFlt1/PlGF Ratio at Obstetric Emergencies

AngioCHIC : Interest of sFlt1/PlGF Ratio at Obstetric Emergencies

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: Centre Hospitalier Intercommunal Creteil · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

In patients with suspected placental vascular disease who do not require hospitalization, the use of the sFlt-1 (Soluble FMS like tyrosin-kinase-1)/PlGF (Placental Growth Factor)/ assay can most likely help teams to define the best possible management.

Detailed description

Preeclampsia is a serious obstetric condition, affecting 2 to 5% of pregnancies and associated with maternal hypertension and renal dysfunction. It is a constant concern of obstetrical teams in the pre and post partum period. In case of diagnosis in the emergency unit, patients are usually hospitalized. However, in the case of a diagnosis of preeclampsia has been invalidated, but in presence of isolated or frustrated clinical functional signs, in the case of a history of placental vascular pathology, obstetric teams implement surveillance strategies that are binding on the patients. The sFlt-1/ PlGF assay has a high negative predictive value for the coming week. The use in clinical practice of these two biomarkers in the indication of negative prediction at one week could help teams in their management but the interest of this use needs to be evaluated.

Conditions

• Suspected Placental Dysfunction, Ruled Out
• Pregnancy Complications
• Pre-Eclampsia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Diagnostic test	During a vascular check-up usually prescribed, an additional blood sample is taken to allow the determination of the sFlt1/PlGf ratio.

Timeline

• Start date: 2019-11-18
• Primary completion: 2023-11-01
• Completion: 2023-12-01
• First posted: 2019-11-20
• Last updated: 2023-06-07

Locations

1 site across 1 country: France