NCT04164056

Hippocampal and Thalamic DBS for Bilateral Temporal Lobe Epilepsy

Hippocampal and Thalamic Deep Brain Stimulation for Bilateral Temporal Lobe Epilepsy

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 12 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The study aims to compare the safety and effectiveness of deep brain stimulation of the hippocampus and the anterior nucleus of the thalamus for reducing the frequency of seizures in patients with bilateral temporal lobe epilepsy.

Detailed description

The outcome of resective surgery for bilateral temporal lobe epilepsy (BTLE) is poor. Neuromodulation such as deep brain stimulation is an alternative therapy for patients with drug-resistant epilepsy, especially for those not suitable for resective surgery. This prospective, randomized, open-label trial aims to compare the effectiveness of deep brain stimulation of the hippocampus and the anterior nucleus of the thalamus for bilateral temporal lobe epilepsy.

Conditions

• Epilepsy, Temporal Lobe

Interventions

Type	Name	Description
DEVICE	deep brain stimulation	deep brain stimulation on the hippocampus or the anterior nucleus of the thalamus

Timeline

• Start date: 2019-11-01
• Primary completion: 2022-09-01
• Completion: 2024-09-01
• First posted: 2019-11-15
• Last updated: 2019-11-15

Locations

1 site across 1 country: China