NCT04151771

Low-load Blood Flow Restriction Training in COPD

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

Peripheral muscle weakness is a predominant problem in patients with COPD and treated using exercise training in pulmonary rehabilitation. Despite pulmonary rehabilitation being an effective intervention, muscle strength impairment is a persisting problem in COPD patients. Patients have problems to tolerate the high training loads, which are necessary to develop strength. Low-load blood flow restriction training (LL-BFRT) might therefore be an option to enhance muscular response of patients with COPD to strength training. Up to now, no studies investigating LL-BFRT in respiratory diseases are available. The primary outcome of this randomized pilot study is knee extensor muscle strength. Secondary, the study will evaluate if LL-BFRT is well tolerated and feasible in COPD patients attending outpatient pulmonary rehabilitation.

Conditions

• COPD
• Muscle Weakness

Interventions

Type	Name	Description
OTHER	Low-load blood flow restriction training	The intervention group will perform the exercises of the lower limbs using LL-BFRT with an occlusion pressure of 70% of arterial occlusion pressure with low training loads (30% of the 1 repetition maximum).
OTHER	Usual outpatient pulmonary rehabilitation	The control group will perform outpatient pulmonary rehabilitation as established.

Timeline

• Start date: 2019-12-27
• Primary completion: 2023-01-28
• Completion: 2023-01-28
• First posted: 2019-11-05
• Last updated: 2023-04-12

Locations

1 site across 1 country: Switzerland