Trials / Completed
CompletedNCT04151641
Mangoselect®: Characterization, Pharmacokinetics and Bioavailability of Xanthone Metabolites
Evaluation of Absorption and Metabolism of Phenolic Compounds From Mangoselect®, an Extract of Mangosteen. Comparison of Two Versions During a Randomized, Double-blinded and Cross-over Trial
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 10 (actual)
- Sponsor
- Fytexia · Industry
- Sex
- All
- Age
- 18 Years – 60 Years
- Healthy volunteers
- Accepted
Summary
The aim of this study is to compare pharmacokinetics and bioavailability of phenolic compounds, mainly xanthones, from a mangosteen extract, either ingested in a dry powder form or in an encapsulated form. Absorption and metabolism will be determined by measuring urinary excretion of phenolic metabolites and blood metabolic profile over 72 hours by means of High Pressure Liquid Chromatography (HPLC) coupled with tandem mass spectroscopy. The design of this study is a cross-over, double-blind and randomized trial on 10 healthy subjects.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIETARY_SUPPLEMENT | MNGDPF | Standardized mangosteen extract in dry powder form |
| DIETARY_SUPPLEMENT | MNGEF | Standardized mangosteen extract in encapsulated form |
Timeline
- Start date
- 2019-11-11
- Primary completion
- 2019-12-17
- Completion
- 2019-12-17
- First posted
- 2019-11-05
- Last updated
- 2020-02-07
Locations
1 site across 1 country: Spain
Source: ClinicalTrials.gov record NCT04151641. Inclusion in this directory is not an endorsement.