NCT04141449

A Multilevel Intervention to Improve Timely Cancer Detection and Treatment Initiation

A Multilevel Intervention (Potlako+) to Improve Timely Cancer Detection and Treatment

• Status: Active Not Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 874 (actual)
• Sponsor: Brigham and Women's Hospital · Academic / Other
• Sex: All
• Age: 30 Years
• Healthy volunteers: Accepted

Summary

This study evaluates whether the Potlako+ intervention of community education, clinical provider support, and patient navigation can improve access to cancer case for patients presenting with symptoms of cancer. Half of communities will receive the Potlako+ intervention, while the other communities will continue to receive standard programs.

Detailed description

The Potlako+ trial is a pair-matched, community-randomized study involving 20 rural and peri-urban communities in Botswana (population \~190,100 with \~100,000 30 years or older). Communities will be randomized 1:1 to the Potlako+ intervention versus standard care. The goal of the intervention is to identify individuals with symptoms/signs suggestive of cancer and expedite diagnosis (and treatment). The trial includes a community education component focused on cancer awareness and importance of early diagnosis and a patient navigation component that aims to expedite the diagnostic evaluation. Community education will be directed at approximately 50,000 community residents (30 years and older). We anticipate approximately 1500 cancer suspects will be identified by their clinic providers.

Conditions

• Neoplasms
• Hiv
• Cervical Cancer
• Breast Cancer
• HNSCC
• Vulvar Cancer
• Anal Cancer
• Cancer Suspect

Interventions

Type	Name	Description
OTHER	Potlako intervention	Combined provider, patient, and health system intervention to expedite cancer diagnosis and care.
OTHER	Enhanced care	Provider education and limited patient counseling.

Timeline

• Start date: 2020-11-18
• Primary completion: 2026-09-30
• Completion: 2026-09-30
• First posted: 2019-10-28
• Last updated: 2025-12-31

Locations

1 site across 1 country: Botswana