NCT04137276

Effect of Intravenous Vitamin C on SOFA Score Among Septic Patients

Effect of Intravenous Vitamin C on Sequential Organ Failure Assessment (SOFA) Score Among Septic Patients: Randomized Controlled Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 33 (actual)
• Sponsor: Indonesia University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to explore the effect of intravenous (IV) vitamin C on sequential organ failure assessment (SOFA) score among septic patients in intensive care unit (ICU).

Detailed description

"This study was approved by the Ethics and Research Committee of Universitas Indonesia. This study was a randomized clinical trial held from April to July 2019 in Cipto Mangunkusumo Hospital. 33 patients that met the inclusion criteria were included in the study. Subjects were divided into two groups: group A (intervention group, n = 18) received parenteral infusions of 1,5 g/6 hours of vitamin C and 200 mg thiamine, while group B (control group, n = 15) received 200 mg thiamine only. baseline demographic data was recorded on the first day. SOFA score was recorded at baseline, 24 hours, 48 hours, and 72 hours after treatment. Data were analyzed using SPSS (Statistical Package for Social Sciences) software."

Conditions

• Sepsis

Interventions

Type	Name	Description
DRUG	vitamin C, vitamin B1	vitamin C 1,5 g/6 hours IV + thiamine 200 mg/12 hours for 3 days
DRUG	vitamin B1	thiamine 200 mg/12 hours for 3 days

Timeline

• Start date: 2019-04-01
• Primary completion: 2019-07-31
• Completion: 2019-07-31
• First posted: 2019-10-24
• Last updated: 2020-01-02

Locations

1 site across 1 country: Indonesia