NCT04131296

Lung Bacteriobiota and Influenza Mortality

Association of Lung Bacteriobiota With Intensive Care Unit Mortality in ARDS Patients: MicroFlu Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 64 (estimated)
• Sponsor: University of Bordeaux · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Influenza is a potentially lethal disease still responsible for thousands excess deaths both in Europe and the United States. Despite the use of neuraminidase inhibitors, its treatment is mostly based on symptomatic care. Lung microbiota has been shown to be involved in the immunity against influenza and is correlated with lung inflammation in numerous chronic respiratory diseases. We therefore aim to analyse the correlation between lung bacteriobiota and influenza ICU mortality

Detailed description

Influenza is a viral disease which is still responsible for thousands of excess deaths par year both in Europe and in the US. Despite the use of neuraminidase inhibitors, its treatment is mostly based on symptomatic care. As lung microbiota is correlated with lung inflammation in numerous chronic respiratory diseases, we hypothesize that lung microbiota would be correlated with influenza outcomes. In a pilot study, we found that lung bacteriobiota but not mycobiota is associated with influenza ICU mortality. We therefore aim to confirm this correlation between lung bacteriobiota and influenza mortality.

Conditions

• Influenza
• Critical Illness

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	influenza screening	positive influenza screening

Timeline

• Start date: 2019-12-01
• Primary completion: 2020-04-30
• Completion: 2020-04-30
• First posted: 2019-10-18
• Last updated: 2019-11-01

Locations

3 sites across 1 country: France